麻杏石甘汤对放射性肺炎急性期的干预作用

Intervention of Maxing Shigan Decoction on Radiation Pneumonitis in Acute Phase

目的:观察麻杏石甘汤对放射性肺炎症状的干预作用。方法:将50只SD大鼠中10只分为阴性对照组,40只复制放射性肺炎模型,依据不同的给药方式将40只模型大鼠分为模型组、麻杏石甘汤高剂量组、麻杏石甘汤中剂量组、麻杏石甘汤低剂量组,连续给药8周。分别于第2周、第4周、第8周随机各处死3、3、4只大鼠,取标本备用。观察大鼠的整体状况及肺组织病理改变。结果:将50只SD大鼠中10只分为阴性对照组,40只复制放射性肺炎模型,依据不同的给药方式将40只模型大鼠分为模型组、麻杏石甘汤高剂量组、麻杏石甘汤中剂量组、麻杏石甘汤低剂量组,连续给药8周。分别于第2周、第4周、第8周随机各处死3、3、4只大鼠,取标本备用。观察大鼠的整体状况及肺组织病理改变。结论:麻杏石甘汤对放射性肺炎急性期有干预作用,可改善放射性肺损伤。

Objective： To determine the intervention of Maxing Shigan Decoction on the symptoms of radiation pneumonitis. Methods： Ten of 50 SD rats were negative control group, and 40 replicated model rats with radiation pneumonitis were divided into model group, Maxing Shigan Decoction groups （high-dose group, middle-dose group, low-dose group） according to different methods of administration, and given 8 weeks of continuous administration. Respectively in the 2rid week, 4th week and 8th week, 3, 3 and d rats of Maxing Shigan Decoction groups were sacrificed randomly, samples were taken as substitutes. The overall condition and the pathological changes of lung tissues were examined. Results ： （j） After irradiation, the overall state and lung tissues changed; （~）Maxing Shigan Decoction can significantly improve the overall state and the pathological changes of rats with radiation pneumonitis in the acute phase. Conclusion： Maxing Shigan Decoction has intervention on acute radiation pneumonitis in the acute phase, it can improve the radiation-induced lung injury.