1Lomas DA,M ahadeva R.A lpha 1 antitryp sin polymerisation and the serp inopath ies:pathobio logy and prospects for treatment[J].JClin Invest,2002,110:1585-1590.
2Lim S,Roche N,O liver BG,et al.Balance of matrix metallop rotease 29 and tissue inh ibito r of metallop ro tease-1 from alveo larm acrophages in cigarette smokers.Regulation by interleuk in-10[J].Am J Resp ir Crit CareM ed,2000,162:1355-1360.
3Steven D,Shapim,Nir M,et a 1.Neutrophil elastase contribute to cigarette smoke-induced emphysema in mice[J].Am J Pathol,2003,163:2329-2335.
4Kishloka C,Okamoto K.Regulation of secretion from mucous and serous cells in the excised ferret trachea[J].Respir Physiol,2001,126:163-171.
5Vignola AM,Paganin F.Airway Remodeling Assessed by Sputum and HRCT in Asthma and COPD[J].Eur Respir J,2004,24:910-917.
8Churg A,Wang RD,Tai H,et al.Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumornecrosis factor-αrelease[J].Am J Respir Crit Care Med,2003,167:1083-1089.
9Pi Stefawo A,Capelli A,Lusuardi M,et al.Severity of airflow limitation is associated with severity of airway inflammation in smokers[J].Am J Respir Crit Care Med,1998,158:1277-1285.
5Tashkin DP,Cooper CB. The role of long-acting bronchodilators in themanagement of stable C0PD[J]. Chest,2004,125:249-259.
6Disse B. Antimusearinic treatment for lung diseases from research toclinical practic;e[J]. Life Sci ,2001,68:2257-2564.
7马爱群,余保平.内科学[M].北京:人民卫生出版社,2011:256.
8Lomas DA,Mahadeva R.Alpha1antitryp sin polymerisatiom and the serp inopathies:pathobio logy and prospects for treatment[J].J Clin Invest,2002,110(11):1585-1590.
9Vignola AM,Paganin F.Air way Remodeling Assessed by Sput u m ang H RCT i n Asth ma and COPD[J].Eu r Respi r J,2004,24(6):910-917.