经鼻持续呼吸道正压通气、利多卡因雾化救治百日咳综合征憋气患者疗效观察

Clinical investigation on treatment of pertussis syndrome with nosal continuous positive airway pressure and lidocaine nebulization

目的探讨经鼻持续呼吸道正压通气(NCPAP)、利多卡因雾化救治百日咳综合征憋气的疗效。方法选择伴有憋气的百日咳综合征患儿53例,随机分为两组,对照组27例予常规治疗和鼻导管给氧,观察组26例在常规治疗基础上配合NCPAP及利多卡因雾化吸入治疗。结果观察组在憋气Apgar评分改善1个级别天数、憋气消失天数、痉咳消失天数、喷嚏危象出现率、肺部并发症出现率等指标明显优于对照组,差异有统计学意义。结论经鼻持续呼吸道正压通气、利多卡因雾化在百日咳综合征憋气的急救中,可迅速控制病情,防止恶化,缩短病程。

Objective To observe the treatment effects of pertussis syndrome with nosal continuous positive airway pressure （NCPAP） and Lidocaine Nebulization. Methods Fifty-three infants with pertussis syndrome were administered with different therapies. Twenty-seven infants as the control group received the comprehensive treatment. Twenty-six infants as the treatment group received NCPAP and lidocaine nebulization on the basis of comprehensive treatment. Results There were significant differences in the time of breathing obstruction Apgar score improved, breathing obstruction disappeared, convulsive cough disappeared between the two groups. In contrast to the control group, the treatment group had significantly fewer cases of asphyxia risk and lung complication. Conclusion The efficacy of NCPAP and lidocaine nebulization are good in treatment of pertussis syndrome. They can decrease the symptom rapidly and shorten the course of disease.