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放疗联合化疗对乳腺癌MCF-7细胞凋亡及周期分布的影响 被引量：2

The Influence of Radiotherapy Combined with Chemotherapy on Apoptosis and Cell Cycle Distribution in Breast Cancer MCF-7 Cell Line
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摘要 [目的]研究放射治疗联合乳腺癌化疗方案NP(NVB+DDP)对人乳腺癌MCF-7细胞凋亡及细胞周期分布的影响。[方法]通过形态学和流式细胞术对MCF-7细胞的凋亡诱导效应进行定性及定量观察,并对细胞周期分布进行分析。[结果]单纯放疗组可诱导MCF-7细胞阻滞在G2/M期。单纯放疗组和单纯化疗组的凋亡指数随时间延长而增加。放化组照射后24h,在4Gy、6Gy和8Gy不同照射剂量下,4Gy出现凋亡峰值,凋亡指数4Gy>6Gy>8Gy,表现为低剂量辐射联合化疗有较好的凋亡诱导效应。[结论]放疗联合化疗对乳腺癌的凋亡诱导效应明显,并呈一定的时间—剂量选择性。
作者 丁祥 李文辉 王熙才 蒋永新
机构地区 云南省肿瘤医院 昆明医学院第三附属医院 云南省肿瘤研究所
出处 《肿瘤学杂志》 CAS 2012年第1期34-36,共3页 Journal of Chinese Oncology
关键词 放射疗法 药物疗法 凋亡 乳腺肿瘤
分类号 R737.9 [医药卫生—肿瘤]
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参考文献9

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同被引文献18

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  • 9罗利民.电离辐射对肺癌A549细胞凋亡及细胞周期的影响[J].肿瘤学杂志,2009,15(5):410-411. 被引量：7
  • 10赵郁,邰智慧,赵建红,李明,徐卫国.早期乳腺癌保乳手术治疗68例临床分析[J].中国妇幼保健,2009,24(33):4660-4662. 被引量：14

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肿瘤学杂志
2012年 第1期

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