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检测膀胱移行细胞癌患者尿液中IGF-Ⅰ、Ⅱ和IGFBP3、5水平的意义 被引量：2

Significance of Detecting Urine IGF-Ⅰ,Ⅱ and IGFBP3,5 in Patients with Transitional Cell Carcinoma of Bladder
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摘要 [目的]探讨胰岛素样生长因子Ⅰ、Ⅱ(IGF-Ⅰ、Ⅱ)和胰岛素样生长因子结合蛋白3、5(IGFBP3、5)在膀胱移行细胞癌患者尿液中水平及其临床意义。[方法]27例膀胱移行细胞癌标本来自2008年1月至2009年4月嘉兴市第一医院手术治疗的患者,采用ELISA法检测患者术前和术后尿液标本中IGF-Ⅰ、Ⅱ和IGFBP3、5水平。[结果]膀胱移行细胞癌患者尿液中IGF-Ⅰ、IGFBP3和IGFBP5术前分别为11.02±59.34、17.78±9.23和3.81±3.19,术后分别为245.29±98.86、18.28±6.69、2.76±3.56,术前、术后无显著差异(P>0.05);IGF-Ⅱ在术前尿液中高达2718.59±3216.89,术后明显下降到1170.62±914.95,术前、术后比较有统计学差异(P<0.05)。[结论]测定膀胱移行细胞癌患者尿液中的IGF-Ⅱ对诊断和随访有临床意义。
作者 何屹 丁韧烨 刘建迪 王华 顾燕琴 蒋振华 俞增福 侯岩松 陈昊 陆林峰 邬凌峰
机构地区 嘉兴市第一医院
出处 《肿瘤学杂志》 CAS 2012年第1期49-50,共2页 Journal of Chinese Oncology
基金 浙江省医学会临床科研基金项目(2007ZYC48)
关键词 胰岛素样生长因子 膀胱肿瘤 移行细胞癌 尿液 酶联免疫吸附实验
分类号 R737.14 [医药卫生—肿瘤]
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参考文献7

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同被引文献23

  • 1王虹,万毅新.IGF_1及IGFBP_3在肿瘤中的研究进展[J].国外医学（内科学分册）,2004,31(8):347-350. 被引量：4
  • 2孙继兴,赵刚,杨雅静,等.恶性肿瘤患者血清、胸水、腹水、囊肿液、尿液中胱抑素C和可溶性尿激酶受体水平的测定[J].中国老年医学,2011,31:498.
  • 3Gamagedara S, Gibbons S, Ma Y. Investigation of urinary pteri- dine levels as potential biomarkers for noninvasive diagnosis of cancer[J]. Clin Chim Acta, 2011, 412 (1 -2):120 - 128.
  • 4卿笃桔,龚志军,陈学中.大肠癌患者尿液层粘连蛋白检测及临床意义[J].现代肿瘤学,2008,16(1):60一62.
  • 5Khadjavi A, Barbero G, Destefanis P, et al. Evidence of abnor- mal tyrosine phosphorylated proteins in the urine of patients with bladder cancer: the road toward a new diagnostic tool[ J] ? J Urol,2011,185(5) : 1922 -1929.
  • 6Wu T, Giovannucci E, Welge J, et al. Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening : a meta-analysis [ J ]. Br J Cancer, 2011, 105 ( 1 ) : 65 -73.
  • 7Serizawa RR, Ralfkiaer U, Steven K, et al. Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diag- nostic value of FGFR3 mutations and hypermethylation events [J]. Int J Cancer, 2011, 129(1):78-87.
  • 8Barocas DA, Motley S, Cookson MS, et al. Oxidative stress measured by urine F2-isoprostane level is associated with pros- tate cancer[J]. J Urol, 2011, 185(6) :2102 -2107.
  • 9王一,孙光,刘晓强,等.荧光原位杂交在尿路上皮癌诊断中的应用[J].2011,38(3):148-150.
  • 10Fujita K, Ewing CM, Isaacs WB, et al. Immunomodulatory IL- 18 binding protein is produced by prostate cancer ceils and its levels in urine and serum correlate with tumor status[J]. Int J Cancer, 2011, 129(2) :424 -432.

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肿瘤学杂志
2012年 第1期

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