胱抑素C与超敏C反应蛋白联合检测诊断2型糖尿病早期肾损害的临床价值

The clinical value analysis of cystatin C and high-sensitivity C-reactive protein co-detection in diagnosis of early renal damage of type 2 diabetes

目的探讨胱抑素C与超敏C反应蛋白联合检测诊断2型糖尿病早期肾损害的临床价值,旨在为临床治疗提供进一步的指导依据。方法选择我院2009年1月～2010年1月入院治疗的2型糖尿病(T2DM)患者62例作为观察对象,另选择35例健康体检者作为对照组,采用免疫比浊法检测胱抑素C和超敏C反应蛋白水平,并应用统计学方法进行统计分析。结果 DM肾功能损害组CysC、hs-CRP明显高于DM肾功能正常组及健康对照组,各组间比较差异有统计学意义(P<0.05)。CysC、hs-CRP联合检测的阳性率明显高于CysC、hs-CRP单一指标检测,差异有统计学意义(P<0.05)。结论胱抑素C与超敏C反应蛋白联合检测诊断2型糖尿病早期肾损害优于单项指标检测,值得推广和应用。

Objective To investigate the clinical value of cystatin C and high-sensitivity C-reactive protein co-detection in diagnosis of early renal damage of type 2 diabetes, designed to provide further guidance on clinical basis. Methods 62 patients with type 2 diabetes （T2DM） in our hospital from January 2009 - January 2010 were selected as the subjects of observation, another 35 healthy volunteers were selected as the control group, using immunoturbidimetric assay for cystatin C and C-reactive protein levels, and application of statistical methods for statistical analysis. Results DM renal dysfunction group CysC, hs-CRP was significantly higher than the DM group with normal renal function and healthy control group, and the difference was statistically significant, P 〈 0.05; CysC, hs-CRP joint detection was significantly higher than CysC, hs-CRP testing as a single indicator, the difference was statistically significant, P 〈 0.05. Conclusion Cystatin C and high-sensitivity C-reactive protein co-detection in diagnosis of type 2 diabetes is better than individual indicator of early detection of renal damage, should be promoted and applied.