骨化三醇联合钙对老年性骨质疏松防治效果的研究

Effect of calcitriol and calcium on prevention and treatment of senile osteoporosis

目的骨化三醇联合钙对老年性骨质疏松防治效果的观察。方法选取我院干部保健中心的老年男性骨质疏松患者108例,随机分成治疗组和对照组各54例。对照组每天口服钙加VD,治疗组加服骨化三醇,连续治疗1年。治疗前,治疗后1年分别检测腰椎,股骨颈BMD,骨代谢指标(BAP),血钙、磷、肝肾功能、血、尿常规等。结果治疗1年后,治疗组腰椎,股骨颈BMD较治疗前有显著增加(P<0.05),骨代谢指标(BAP)下降明显(P<0.05)而血,尿常规,等生化指标无明显异常。对照组治疗前后无明显变化(P>0.05)。

Objective To study the Calcitriol and calcium on prevention and treatment of senile osteoporosis. Methods Separated 108 cases of male patients with senile osteoporosis from health center into two groups, treatment group （54 cases） and control group （54 cases）. The control group took calcium and VD qd for 1 year. The treatment group took calcium, VD and calcitriol qd for 1 year. The two groups both checked BMD of lumbar vertebra and neck of femur and BAP, serum calcium and phosphorus,liver and renal functions,blood routines and urine routines before treatment and after treatment for 1 year. Results BMD of lumbar vertebra and neck of femur were more significantly increased than before treatment （P 〈 0.05） and BAP were more significantly decreased than before treatment （P 〈 0.01）, but blood routines ,urine routines and biochemistry indexes did not find abnormality in the treatment group after treatment for 1 year. Those data of control group were not more significantly changed than before treatment （P 〉 0.05）. Conclusion Calcitriol and calcium have obvious effect to improve the osteoporotic states of senile osteoporosis.