α1b干扰素联合苦参素治疗慢性乙型肝炎疗效观察

Interferon α-1b combined with oxymatrine in treating chronic hepatitis B

目的评价α1b干扰素联合苦参素治疗慢性乙肝的疗效。方法将88例慢性乙型肝炎患者随机分为两组,治疗组44例,应用α1b干扰素500万单位肌内注射,每日1次,2周后改为隔日1次,苦参素胶囊200 mg,每日3次,疗程6个月;对照组44例,应用苦参素胶囊200 mg,每日3次,疗程6个月,观察两组的肝功复常率、HBeAg阴转率及HBV DNA阴转率。结果治疗组与对照组比较其肝功复常率、HBeAg阴转率、HBV DNA阴转率分别为93.18%、63.64%、70.45%和86.36%、13.64%、11.36%。结论α1b干扰素联合苦参素治疗慢性乙肝有较好的疗效,其HBeAg阴转率及HBV DNA阴转率均明显优于单用苦参素组,但因本组例数少,值得临床进一步研究应用。

Objective To evaluate the clinical effect of interferon α1b combined with oxymatrine in treating chronic hepatitis B. Methods All of 88 patients with chronic hepatitis B were divided into two groups randomly, 44 patients in the treatment group were given Interferon α1b 5xlOrU of intramuscular injection, once a day, two weeks later changed to α1b 5×106Uonce every other day for 6 months, combined with Oxymatrine capsule 200 mg, 3 times a day for 6 months, 44 patinents in the control group were given Oxymatrine capsule 200 mg,3 times a day for 6 months. Liver function test, HBeAg and HBVDNA turned to negative rate were compared between the two groups. Results The treatment group and the control group to compare their liver function recovery rate, HBeAg turned to negative rate, HBV DNA turned to negative rates were 93.18%, 63.64%, 70.45% and 86.36%, 13.64%, 11.36%. Conclusion Interferon α1b combined with Oxymatrine in treatment of chronic hepatitis B has better therapeutic effect, the HBeAg and HBV DNA negative conversion rate are superior to the single use of Oxymatrine group.But the cases have not enough,it is worthy of further clinical research and application.