肝癌患者肝移植术后行FOLFOX化疗的护理

Nursing intervention for patients undergoing FOLFOX chemotherapy after liver transplantation

目的探讨肝癌患者肝移植术后行奥沙利铂+卡培他滨+左亚叶酸钙(FOLFOX)化疗的护理体会。方法2008年7月～2011年7月,本院对63例肝移植术后患者应用FOLFOX方案进行化疗,总结患者化疗期间的护理要点。结果63例患者共完成268个周期的化疗,出现末梢神经异常48例,恶心和呕吐41例,腹泻32例,骨髓抑制36例,口腔黏膜炎(溃疡)11例,静脉炎1例。结论肝癌患者肝移植术后行FOLFOX化疗会出现比较严重的不良反应,针对FOLFOX的特点实施针对性的护理措施,可以降低化疗药物的毒副反应,减轻患者化疗的痛苦,从而提高患者的生存质量。

Objective To investigate the experience of nursing hepatocellular carcinoma patients undergoing capecitahiue, oxaliplatin and calcium leucovorin （FOLFOX） chemotherapy after liver transplantation. Method The clinical data of 63 hospitalized hepatocellular carcinoma patients undergoing FOLFOX chemotherapy after liver transplantation during July 2008 to July 2011 were reviewed to summarize the key nursing points of nursing. Result 63 patients completed a total of 268 cycles of chemotherapy： peripheral nerve abnormalities occurred in 48 cases, nausea and vomiting in 41, diarrhea in 32, fione marrow suppression in 36, 11 oral mucositis （ulcers）, and phlebitis in 1 case. Conclusion The nursing intervention pertinent to FOLFOX chemotherapy may reduce the toxicity of chemotherapeutics, relieve the pains and thus improve patient＇s quality of life.