依那普利联合硝苯地平控释片治疗原发性高血压疗效观察

Effect observation of enalapril combined with nifedipine in treatment of essential hypertension

目的探讨依那普利联合硝苯地平控释片治疗原发性高血压的疗效。方法将106例原发性高血压患者随机分为治疗组和对照组各53例。治疗组予依那普利胶囊5mg口服,每天2次;硝苯地平10mg口服,每天3次。对照组单用依那普利,用法同治疗组。2组均连续服用21d为1个疗程。观察2组临床疗效和血压变化情况。结果治疗组总有效率为94.3%高于对照组的83.0%,差异有统计学意义(P<0.05)。2组治疗后收缩压和舒张压均低于治疗前,差异均有统计学意义(P<0.05);治疗组治疗后血压低于对照组,差异有统计学意义(P<0.05)。结论依那普利联合硝苯地平控释片治疗原发性高血压具有良好的协同作用,可有效控制患者血压水平。

Objective To discuss the effect of enalapril combined with nifedipine in treatment of essential hypertension.Methods 106 cases patients with essential hypertension were randomly divided into treatment group and control group,each of 53 cases.Treatment group were treated with enalapril capsules 5mg orally,2 times a day;Nifedipine 10mg orally,3 times a day.Control group were received enalapril with the same method as treatment group.Both groups were treated for 21d as a continuous course of treatment.Observed clinical efficacy and blood pressure change of two groups.Results The total effective rate of treatment group(94.3%) was higher than that of control group(83.0%) ,the difference was statistically significant(P<0.05) .After treatment,systolic and diastolic blood pressure of twogroups were lower than those before treatment,the difference were statistically significant(P<0.05) ;After treatment,blood pressure of treatment group was lower than that of control group,the difference was statistically significant(P<0.05) .Conclusion Enalapril combined with nifedipine in treatment of essential hypertension has a good synergistic effect,can effectively control blood pressure level.