别嘌醇干预对急性冠状动脉综合征患者高尿酸血症、高脂血症的影响

The effect of intervene allopurinol of hyperuricemia and hyperlipidemia of patient with acute coronary syndrome prognosis

目的探讨别嘌醇干预对急性冠状动脉综合征患者高尿酸血症、高脂血症的影响。方法将急性冠状动脉综合征患者80例随机分为治疗组和对照组各40例。观察组在按冠心病二级预防的基础上加用别嘌醇100mg口服,每天3次;对照组按冠心病二级预防治疗。治疗后观察2组患者尿酸及血脂变化,并观察其预后。结果治疗组治疗后尿酸(UA)、三酰甘油(TG)、总胆固醇(CHO)、低密度脂蛋白(LDL)明显改善,且低于对照组,差异均有统计学意义(P<0.01)。治疗组临床并发症发生率低于对照组,预后优于对照组,差异均有统计学意义(P<0.05)。结论高尿酸血症、高脂血症对急性冠状动脉综合征患者有很重要的影响,对急性冠状动脉综合征伴高尿酸血症、高脂血症患者应进行积极治疗。

Objective To discuss the effect of intervene allopurinol of hyperuricemia and hyperlipidemia of patient with acute coronary syndrome.Methods 80 cases patients with acute coronary syndrome were divided into treatment group and control group,each of 40 cases.Treatment group based on the secondary prevention of coronary heart disease used allopurinol 100mg orally,3 times a day;Control group were given the secondary prevention of coronary heart disease treatment.After treatment,observed the change of uric acid and blood lipid,and observed the outcome.Results After treatment,the uric acid(UA) ,triglycerides(TG) ,total cholesterol(CHO) ,low density lipoprotein(LDL) significantly improved,and were lower than those of control group,the difference were statistically significant(P<0.01) .The clinical complication rate was lower than that of control group,the prognosis was better than control group,the difference were statistically significant(P<0.05) .ConclusionHyperuricemia and hyperlipidemia in patient with acute coronary syndrome have a significant impact,to patient with acute coronary syndrome associated with hyperuricemia and hyperlipidemia should be actively treated.