补肾益气法与单纯补肾法治疗慢性再生障碍性贫血的临床疗效比较

Comparing Two Methods of the Clinical Study on Treatment of Chronic Aplastic Anemia: Invigorating the Kidney only and Invigorating the Kidney and Qi both

[目的]比较补肾益气法与单纯补肾法治疗慢性再生障碍性贫血(CAA)的临床疗效。[方法]将72例CAA患者随机分为"单纯补肾组"34例,"补肾益气组"38例,在均予雄激素联合环孢素为基础治疗的同时,分别给予对应中医辨证中药,治疗3个月后观察患者外周血淋巴细胞亚群、细胞因子变化,并进行中医症候评分及疗效评价。[结果]补肾益气组总有效率88.89%,单纯补肾组总有效率83.87%,无显著性差异(P>0.10),但补肾益气组基本治愈率及缓解率优于单纯补肾组(P<0.10)。治疗后患者外周血细胞CD3、CD4升高,CD8降低,细胞因子IFN-γ、TNF-α降低,且补肾益气组较补肾组明显,两组比较有显著性差异(P<0.05)。[结论]治疗3个月后发现,补肾益气法治疗慢性再障疗效显著,总有效率与单纯补肾法无显著性差应,但能明显改善慢性再障患者的中医临床证候,升高外周血象,调节细胞因子,促进骨髓造血功能恢复,且较补肾益气组显著。

[Objective] To compare the clinical effect on treatment of chronic aplastic mnemia（CAA） between the methods of invigorating the kidney only and the methods of invigorating the kidney and Qi both.[Methods] Put 72 CAA patients into two groups randomly.34 patients in kidney group and 38 patients in Qi group.Two groups were treated with androgen and cyclosporine A fairly but treated with different herbs at the same time and see the result of medical examination of the patients after 3 months.[Resules] The total effective rate of Qi group was 88.89%,simultaneity the kidney group reached 83.87%,no significant difference（P〉0.10）.But the cure rate（CR） and the relieve rate（RR） of the Qi group were better than the kidney group（P〈0.10）.[Conclusion] The method of invigorating the kidney and Qi had better curative effect than the methods of invigorating the kidney only.