慢性乙型肝炎中医证型与临床检验指标相关性研究

Relativity Research on Chronic Hepatitis B TCM Syndromes and Clinical Test Indexes

[目的]探讨慢性乙型肝炎(CHB)中医证型与临床检验指标之间的关系。[方法]将符合纳入标准的慢性乙型肝炎患者进行中医辨证分为5种证型,因其中3种证型病例数极少或缺乏故予以剔除,留下肝胆湿热证和肝郁脾虚证,检测血清生化指标、血清病毒标志物指标及HBV-DNA,对资料进行检验分析。[结果]AST、ALT、GGT、TBIL、DBIL在肝胆湿热证中较肝郁脾虚证显著升高(P<0.01或P<0.05)。[结论]部分临床检验指标与中医辨证分型中肝胆湿热证和肝郁脾虚证存在相关性,ALT、AST、GGT、TBIL、DBIL可为CHB中医辨证的客观化、标准化提供依据。

[Objective] To observe the relationship between chronic hepatitis B（CHB） TCM types and clinical test indexes.[Method] Make TCM diff-erentiation to 139 cases,owing to regional factors,keep wet and hot liver and gallbladder syndrome（1）,and depressed liver and deficient spleen syndrome（2）,test both serum index,virus symbol index and HBV-DNA,then make analysis to the data.[Result] AST,ALT,GGT,TBIL and DBIL in syndrome 1 are much higher than in syndrome 2,IBIL,HBeAg-positive rate,HBV-DNA positive rate and HBV-DNA have no difference of statistical meaning between them.[Conclusion] Part of clinical test indexes are related with TCM differentiation types;ALT,AST,GGT,TBIL and DBIL can provide base for CHB TCN syndrome objectification and standardization.