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肿瘤抑制基因DAPK:一个新的药物治疗靶点 被引量：1

The Tumor Suppressor Gene DAPK:a Novel Drug Treatment Target
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摘要 死亡相关蛋白激酶(DAPK)是一种新的钙调蛋白(CaM)调节的丝/苏氨酸激酶,是凋亡的正性调节因子。细胞凋亡被认为是控制和治疗肿瘤的最有效方法之一,它与肿瘤的发生、发展和转移有着密切的联系。而DAPK参与多条途径诱导的细胞凋亡,被公认为是一种肿瘤抑制基因。在此我们将重点讨论DAPK促进细胞凋亡的机制,为靶向治疗肿瘤提供方向和理论依据。 Death-associated protein kinase（DAPK） is the founding member of a newly classified family of calmodulin（CaM）-regulated Ser/Thr kinases that functions as a positive mediator of apoptosis.Apoptosis plays an important role in tumor initiation,pro-gression and metastasis,whose regulation may be an effective way for tumor therapeutics.DAPK is considered as an tumor suppressor involved in diverse apoptosis pathways.This review summarizes relevant knowledge of DAPK family with an emphasis on potential mechanisms of DAPK family-mediated apoptosis and its potential to serve as a novel therapeutic target in oncology.
作者 向莎丽 陈幸华 张诚
机构地区 第三军医大学新桥医院血液科
出处 《现代生物医学进展》 CAS 2012年第1期163-165,150,共4页 Progress in Modern Biomedicine
基金 国家自然科学基金(30971109) 重庆市自然科学基金(CSTC2009BA5011)
关键词 死亡相关蛋白激酶 凋亡 肿瘤 Death-associated protein kinase（DAPK） Apoptosis Tumor
分类号 R730.5 [医药卫生—肿瘤]
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参考文献26

  • 1Alison M. Michie, Alison M. McCaig, et al. Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer[J]. FEBS.J, 2010, 277: 74-80.
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  • 3Gozuacik D, Bialik S, Raveh T, et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death[J]. Cell Death Differ, 2008, IS: 1875-1886.
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二级参考文献2

共引文献13

同被引文献23

  • 1Deiss LP, Feinstein E, Berissi H, et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as po- tential mediators of the gamma interferon- kced cell dmlh[J]. Gta Dev,1995,9( 1):15-30.
  • 2Michie AM, McCaiq AM, Nakaqawa R, et al. Death-associated protein kinase (DAPK) and signal transduction: regulation in can- cer[J]. FEBS J, 2010, 277(1): 74-80.
  • 3Raveh T, Berissi H,Eisenstein M,et al. A functional genetic screen identifies regi- ons at the C-terminal tail and death-domain of death-associated protein kinase that are critical for its proapoptotic activity[J].Proc Nail Acad Sci USA, 2000, 97(4) : 1572-1577.
  • 4Benderska N, Schneider-Stock R. Tran- scription control of DAPK[J]. Apoptosis, 2014,19(2): 298-305.
  • 5Odma S, gancifilVt RauTr, et ala3eafla-as cimed protein kinase controls STAT3 activ-ity in intestinal epithelial cells[J]. Am J Pathol,2013,182(3):1005-1020.
  • 6Gade P, Roy SK, Li H,et al. Critical role for trascriplion factor C/EBP-b in tgu/afi the expression of death-associated protein kse 1 [J]. Mol Cell Biol, 200828(8): 2528-2548.
  • 7Benderska N, Schneider-Stock R. Tran- scription control of DAPK[J]. Apoptosis, 2014,19(2): 298-305.
  • 8Chen HY, Lee YR, Chen RH.The functions and regulations of DAPK in cancer meta- stasis[J]. Apoptosis,2014,19(2): 364-370.
  • 9Gallagher PJ, Blue EK. Post-translational regulation of the cellular levels of DAPK [J]. Apoptosis,2014,19(2): 306-315.
  • 10Toyooka S, Toyooka KO, Miyajima K, et, al. Epigenetie down-regulation of death- associated protein kinase in lung cancers [J]. Clin Cancer Res,2003,9(8):3034-3041.

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现代生物医学进展
2012年 第1期

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