摘要
dynamin家族是一类鸟苷酸三磷酸酶,是细胞在进行内呑过程中特异的一种蛋白,它参与囊泡从细胞膜上出芽和剪切的过程。从低等生物酵母到所有高等生物都发现了dynamin或者其同源物存在。通过对不同物种的基因组序列分析和基因克隆,发现了三种典型dynamin蛋白和几类同源蛋白。它们在不同的器官或者不同的亚细胞结构上行使着不同的功能。通过对dynamin功能域的研究,发现dynamin的PRD结构域能与很多蛋白相互作用。本文主要总结了dynamin家族蛋白和与之相互作用的蛋白。
Dynamins are large GTPases that participate in endocytosis,and are involved in the budding and scission of a wide range of vesicles and organelles.They are found in all of species from yeast to human being.Through whole genomic analysis and positive clone,three classic dynamin and several dynamin like proteins have been found.They play different roles in different organs or different organelles.When studying the domains of dynamin,we notice that there are many proteins can interact with dynamin with a special do-main.
出处
《现代生物医学进展》
CAS
2012年第1期183-185,共3页
Progress in Modern Biomedicine
