碘的生物无机化学研究进展—碘对甲状腺激素生物活性的结构作用探讨

Progress in Study on Bioinorganic Chemistry of Iodine an Approach to Structural Role of the Iodines in Thyroid Hormone Receptor Binding

本文综述甲状腺激素相关研究的进展 ,探讨碘在甲状腺激素与细胞内激素受体蛋白结合中的结构作用。文中评述了关于甲状腺激素与血浆运载蛋白和细胞内受体蛋白结合的溶液亲合性、结构研究和甲状腺激素碘代酚环的分子识别特性与碘的结构效应模拟研究的数据结果 ,并就碘对激素

Thyroid hormone related studies including the affinities of thyroid hormone analogues to serum carrier proteins, the binding structures of the hormone carrier protein and hormone receptor protein complexes, and the molecular recognition properties of the outer phenolic ring of thyroid hormones and the structural effects of the iodines have been reviewed. Possible structural roles of the iodines for thyroid hormone receptor binding have been proposed.