中孕期高水平母血清游离人绒毛膜促性腺激素与子痫前期发生相关性的Meta分析

Relationship Between Elevated Maternal Serum Free Human Chorionic Gonadotropin during Second-trimester and Preeclampsia:A Meta-analysis

目的探讨中孕期高水平母血清游离人绒毛膜促性腺激素与子痫前期发生的关系及其临床应用价值。方法检索Medline、EMBase、PubMed、中国生物医学文献数据库,收集中孕期高水平母血清游离人绒毛膜促性腺激素与子痫前期发生关系的病例对照研究,筛选、评价文献并提取数据进行Meta分析。结果共纳入4篇文献。主要从病例组与对照组方法的选择、病例组与对照组的可比性、接触暴露评估方法 3个方面对文献进行评价。Meta分析结果表明,中孕期高水平母血清游离人绒毛膜促性腺激素与子痫前期发生存在显著的相关性〔OR=2.01,95%CI(1.50,2.69),P<0.00001〕,偏倚分析提示无显著偏倚存在,该结果具有一定的可信度。结论中孕期高水平母血清游离人绒毛膜促性腺激素与子痫前期的发生有关,可用于子痫前期高风险人群的筛查。

Objective To evaluate the relationship between elevated maternal serum free human chorionic gonadotro- pin during second - trimester and development of preeclampsia and its value of clinical application. Methods This is a case - control study in which some cases about the relationship between elevated maternal serum free human chorionic gonadotropin dur- ing second -trimester and preeclampsia were searched out from Medline, EMBase, PubMed and CBMdisc to have the data sif- ted, evaluated and extracted for meta - analysis. Results The author evaluated the four articles being involved in the case - control study finally from three aspects： the selection methods of case and control group used, comparability of the two groups, contact exposure assessment method. Meta- analysis indicated that there were statistical significance between elevated second - trimester maternal serum free human cborionic gonadotropin and development of preeelampsia [ OR = 2. 01, 95% CI （ 1.50, 2. 69）, P 〈0. 00001~, and bias analysis showed little bias among them, so the result was credible to some extent. Conclusion There is significant correlation between elevated maternal serum free human chorionic gonadotropin during second - trimester and development of preeclampsia, which can be used as a screening of high risk population of preeeclampsia.