老年卵巢癌术后腹腔热灌注化疗的毒副作用分析

Toxic and Side Effects of Intraperitoneal Hyperthermic Perfusion Chemotherapy on Advanced Ovarian Cancer Postoperatives

目的探讨腹腔热灌注化疗联合全身静脉化疗在老年上皮性卵巢癌术后辅助治疗的毒副作用。方法 25例老年上皮性卵巢癌患者,分别采用腹腔热灌注化疗+全身静脉化疗(IP组)和单纯全身静脉化疗(IV组),比较两组治疗后的毒副作用。结果两组恶心、呕吐的程度比较,差异有统计学意义(P=0.036);两组血液学毒性、肝肾功能损害、周围神经毒性、腹痛、心脏毒性和发热的程度比较,差异均无统计学意义(P>0.05)。结论腹腔热灌注化疗联合全身静脉化疗作为Ⅱ期以上的老年上皮性卵巢癌术后的一种辅助治疗方法,未增加毒副作用,耐受性好。

Objective To explore the toxic and side effects of treating epithelial ovarian cancer with intraperitoneal hyperthermic chemotherapy（IPHC） plus intravenous chemotherapy after cytoreductive surgery.Methods 25 patients with advanced epithelial ovarian cancer were randomly assigned to receive a combination of IPHC plus venous chemotherapy（IP group） and pure venous chemotherapy（IV group）.We made a comparison between the two groups about the toxic and side effects arising from the respective treatments.Results There was a statistically significant difference between the two groups in terms of nausea severity and vomiting degree（P=0.036）,while no significance could be found in hematological toxicity,liver dysfunction injury,peripheral neurotoxicity,bellyache,cardiac toxicity and fevering degree（P0.05）.Conclusion The combination of IPHC plus venous chemotherapy is an auxiliary treatment method for advanced epithelial ovarian carcinoma above Ⅱ phase after cytoreductive surgery with the advantages of little toxic and side effects and good toleration of the patients.