人工腰椎间盘置换治疗退行性腰椎间盘疾病16例分析

Preliminary clinical results of artificial disc replacement for degenerative disc disease in 16 cases

背景：与传统的单纯腰椎间盘切除和脊柱融合治疗方法相比,人工腰椎间盘置换具有明显的理论优势,已成为治疗退行性腰椎间盘疾病的最有希望的方法。目的：总结人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床疗效。方法：2007-05/2010-10行人工腰椎间盘置换治疗退行性腰椎间盘疾病16例,其中男9例,女7例,平均年龄40.5岁（28~55岁）。结果与结论：随访时间6~36个月,置换后目测类比评分、Oswestry功能障碍指数、椎间隙高度均较置换前有显著改善（P〈0.01）。置换后腰椎活动度获有效维持,置换后腰椎活动度与置换前比较差异无显著性意义（P〉0.05）。结果显示人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床结果令人满意,但其远期效果尚待进一步观察。

BACKGROUND： Simple discectomy and spinal fusion surgery were the classical methods for the degenerative disc disease. Comparing to them, artificial disc replacement （ADR） showed more theoretical superiority. OBJECTIVE： To present the preliminary clinical results of ADR for the treatment of degenerative disc disease. METHODS： From May 2007 to October 2010, ADR were preformed on 16 cases for the treatment of degenerative disc disease. 9 males and 7 females with average age of 40.5 years underwent ADR. RESULTS AND CONCLUSION： The follow-up time averaged 21.5 months （6-36 months）. Postoperative visual analogue scale, Oswestry Disability Index and intervertebral height were significantly improved as compared with those in preoperation （P 0.01）. The postoperative range of motion （ROM） of the involved lumbar segment was effectively kept. The ROM before and after operation showed no significant difference （P 0.05）. ADR can acquire satisfactory preliminary clinical results for the treatment of degenerative disc disease. However, further research is needed to study its long-term impact.