北京地区代谢因素与胆囊结石患病风险的病例对照研究

Metabolism-related Risk Factors of Cholelithiasis among Beijing Residents: A Case-control Study

目的探讨北京地区胆囊结石发生的代谢相关危险因素。方法收集北京协和医院体检中心2007年8月至2010年8月共2270例胆囊结石患者的临床资料,并以同时期4336名健康体检者作为对照,记录所有体检者的既往史、糖尿病史、高血压病史及体格检查情况,同时行胆囊B超和空腹血糖、血脂检测,所有资料汇总后进行统计学处理。结果总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹血糖、体重指数、收缩压为胆囊结石的危险因素,与胆囊结石的发病呈正相关(P<0.05);高密度脂蛋白胆固醇(HDL-C)与之呈负相关(P<0.05),而舒张压与胆囊结石的发生无明显相关性(P>0.05)。结论胆囊结石的形成是多因素作用的结果,血脂、血糖、收缩压以及体重指数升高是北京地区人群胆囊结石患病的危险因素。

To explore the metabolismrelated risk factors of cholelithiasis among residents in Beijing. Methods The clinical data including previous disease history, findings of physical examination, and results of cholecystosonography of 2270 patients with cholelithiasis identified in the Health Screening Center of Peking Union Medical College Hospital between August 2007 and August 2010 were retrospectively reviewed （the case group）. Meanwhile, 4336 healthy individuals during the same period were randomly chosen as the control group. Results Total cholesterol, triglyceride, lowdensity lipoprotein cholesterol, fasting blood glucose, body mass index, and Systolic blood pressure were positively correlated with the incidence of cholelithiasis （ P 〈 0.05 ）, while highdensity lipoprotein cholesterol was negatively correlated （ P 〈 0.05 ）. Diastolic blood pressure showed no association with cholelithiasis （ P 〉 0.05 ）. multiple factors including elevated blood lipids, blood glucose, Conclusion Cholelithiasis is resulted from and systolic blood pressure among residents inBeijing.