N-(3-苯基2 ,3,4-三唑甲酰氨基)-N'-芳酰基硫脲及其环化产物的合成

Synthesis of N-(3-phenyl-2,3,4-triazole formylamino)- N'-aroylthiosemicarbazides and Related Heterocyclic Compounds

以PEG 4 0 0为相转移催化剂 ,通过 2 苯基 1,2 ,3 三唑 4 甲酰基肼与芳酰基异硫氰酸酯的加成反应 ,合成了系列新的酰胺基硫脲衍生物 (3 ) ,3分别在酸性和碱性条件下环化制得相应的 1,3 ,4 噻二唑衍生物和 1,2 ,4 三唑啉 5 硫酮衍生物 ,并经元素分析、IR ,1HNMR和MS确证结构。

A series of new acylthiosemicarbazide derivatives(3) were synthesised by addition reaction of 2 phenyl 1,2,3 triazole 4 formyl hydrazine with aroylisothiocyante under the condition of PTC using PEG 400 as the catalyst. The derivatives 3 were cylized under acidic or base condition to obtain corresponding 1,3,4 thiadiazole or 1,2,4 triazoline 5 thione derivatives, respectively. The structure of all compounds prepared was determined by elemental analysis, IR, 1H NMR and MS.