全固态复合式雷尼替丁电极的研究

A Study on Combined and Full-Solid-State Ranitidine Ion-Selective Electrode

制备了以脲醛树脂、KCl粉末、Ag/ Ag Cl丝为材料的 Ag/ Ag Cl固体电极 ,然后以此固体电极分别作为内外参比电极、以含四苯硼酸雷尼替丁离子对缔合物的 PVC膜作为敏感元件 ,组装成一种全固态复合式雷尼替丁电极 ,并详细研究了其性能。结果表明该电极具有良好的稳定性 ,其 Nernst响应范围为 5× 1 0 - 4～ 1× 1 0 - 1 mol/ L,斜率为 58.7m V/pc,检测下限为 2 .5× 1 0 - 4 mol/ L,使用寿命不少于 6个月 ,能用于盐酸雷尼替丁制剂的含量测定。

Using urea formaldehyde resin, KCl powder and a Ag/AgCl wire as material, a Ag/AgCl solid electrode was prepared. Then using this kind of solid electrode as internal and external reference electrode, respectively,and using a PVC membrance containing ranitidine tetraphenylborate ion pair complex as sensitive element, a combined and full solid state ranitidine ion selective electrode was constructed. The properties of this combined electrode were studied in detail. The results indicated that the combined electrode had a good stability. It exhibited a Nernstian linear range from 5×10 -4 ～ 1×10 -1 mol/L with a slope of 58.7 mV per decade and detection limit of 2.5×10 -4 mol/L. The lifetime of this electrode is at lasts 6 months. It has been used in the potentiometric determination of ranitidine in pharmaceutical preparation.