单扫描示波极谱法测定安乃近含量

Determination of Novalgin by Single-Sweep Oscillopolarography

报道了安乃近的单扫描示波极谱法测定。样品在酸性条件下用碘将其氧化 ,然后在 p H=1 1 .0的氨 -氯化铵缓冲液中 ,起扫电位 -0 .4 0 V ( vs.SCE )测定 -0 .76V处的二次导数峰高。峰高与安乃近浓度在 0 .0 1～ 3 μg/m L范围内呈线性关系。检出限为 0 .0 0 5μg/m L。同时对该氧化产物的极谱行为和反应机理作了探讨。方法用于测定安乃近的含量 ,结果满意。

A method for the determination of novalgin has been described. Novalgin was oxidized by iodine in acidic solution and a sensitive reduction wave of its oxidation product was obstained at-0.76 V ( vs.SCE ) by single sweep oscillopolarography in NH 3·H 2O NH 4Cl buffer solution (pH=11.0). An excellent linear relationship between the peak height and the concentration of novalgin has been found in the range of 0.01～3 μg/mL. The detection limit was 0.005 μg/mL. Furthermore, the polarographic behaviour and the electrode reaction mechanism of its oxidation product were studied. The methods has been applied to the determination of novalgin in tablet with satisfactory results.