bcl-2蛋白在口腔扁平苔藓和口腔鳞状细胞癌中的表达

EXPRESSION OF BCL-2 IN ORAL LICHEN PLANUS AND ORAL SQUAMOUS CELL CARCINOMA

目的:探讨bcl-2在口腔扁平苔藓(OLP)和口腔鳞状细胞癌(OSCC)的表达及意义。方法:运用免疫组化SP法研究bcl-2在糜烂型、非糜烂型OLP,高、中、低分化OSCC中的表达。结果:bcl-2在正常口腔粘膜(NOM)上皮的表达较OLP明显增强,差异具有统计学意义。bcl-2在高、中、低分化OSCC中的表达差异明显,OSCC分化越低,bcl-2表达则越强;分化越高,表达越弱。结论:bcl-2在OLP上皮层中表达较正常口腔粘膜(NOM)上皮明显减少,可能与OLP上皮细胞凋亡增加、上皮变薄有关。bcl-2在高、中、低分化OSCC中的表达具有明显差别,可能与OSCC的分化的程度有关。

Objective： To explore the expression and significance of bcl-2 in oral lichen planus （OLP） and o- ral squamous cell carcinoma （OSCC）. Methods： Immunohistochemical SP method was applied to detect the ex- pression of bcl-2 in erosive , non-erosive OLP and well, moderate,poorly differentiated OSCC. Results： Expres-sion of bcl-2 in NOM epithelium increased more than in OLP and the difference was statistically significant. Ex- pression of bcl-2 in well, moderate and poorly differentiated OSCC were also significantly different. The better the OSCC differentiated, the stronger the bcl-2 expressed; the poorer the OSCC differentiated, the weaker the bcl-2 expressed. Conclusion： Expression of bcl-2 in OLP epithelium significantly less than in NOM epithelium,which may be associated with increased apoptosis of epithelial cells and epithelial thinning in the OLP. Expres- sion of bcl-2 in well, moderate and poorly differentiated OSCC were significantly different, which may be related to the differentiation of OSCC.