P物质、血管活性肠肽在口腔扁平苔藓唾液中的表达

STUDY OF THE EXPRESSION OF SUBSTANCE P AND VASOACTIVE INTESTINAL PEPTIDE IN ORAL LICHEN PLANUS SALIVA

目的:检测P物质(SP)、血管活性肠肽(VIP)在口腔扁平苔藓(OLP)唾液中的表达,并探讨SP、VIP与OLP的关系。方法:采用酶联免疫吸附法(ELISA)检测16例口腔扁平苔藓和正常人唾液中SP、VIP的含量。结果:SP在OLP患者唾液中的含量与正常人唾液中的含量无差异(P>0.05),VIP在OLP患者唾液中的含量高于正常人唾液中含量(P<0.05)。结论:OLP唾液中VIP的表达增高,唾液取材方便,唾液中的VIP含量的测定可能对OLP的疗效检测和预示复发有一定的临床应用价值。

Objective：To examine the expression of substance P（SP） and vasoaetive intestinal peptide（VlP） in oral lichen planus （OLP） saliva samples, and investigate the relationship between them and OLP. Methods ：The concentration of SP and VIP in 16 OLP and normal saliva samples was assayed by ELISA.Results：The differenceof SP concentration in saliva of OLP patients and control group was not significant （P〉0.05）. The difference of VIP concentration in saliva between OLP patients and control group was significant （ P〈O.05）,which meant saliva VIP concentration was higher in OLP patients than in control group. Conclusion：The expression of VIP increased in saliva of OLP patients. Moreover, the collection of saliva samples is convenient in clinic.The determination of saliva VIP may be helpful to monitor therapy and predict recurrence for OLP patients.