“肺络微型癥瘕”与COPD气道重构的相关性探讨

Correlation between micro-accumulation in lung collateral vessels and airway remodeling of chronic obstructive pulmonary disease

气道重构是慢性阻塞性肺病(COPD)的病理关键。运用中医络病学说和癥瘕理论,阐述COPD气道重构与肺络微型癥瘕在病因、病机、病位、病程及转归等方面的相关性和一致性。说明气道重构的发生、发展,实质上是COPD治不得法,迁延不愈,耗伤肺气,津凝成痰,血滞成瘀,痰瘀互相胶结,积聚于肺之络脉,形成微型癥瘕,由瘕聚渐成癥积,进而痹阻肺络的过程。并提出消癥通络为主的治疗原则。

Airway remodeling is the key pathological progress of chronic obstructive pulmonary disease （COPD）. The paper stated the correlation and uniformity between airway remodeling of COPD and micro-accumulation in lung collateral vessels in cause, patbogenesis, location, course and prognosis based on the TCM doctrine of collateral disease and accumulation theory. The occurrence and development of airway remodeling is induced by improper treatment to COPD, so lung-qi is consumed, body fluid coagulates into phlegm, blood stagnates into blood stasis, phlegm and stasis glue together in lung collaterals and then micro-accumulation is formed and blocks lung collateral vessels gradually. The paper also proposed resolving accumulation and freeing collateral vessels as major therapeutic principle. This theory has enriched the TCM theory about lung disease and provides a new idea for improving clinical effect.