含喹喔啉环1,3,4-睧二唑衍生物的合成及结构鉴定

Synthesis of 1,3,4-oxadiazole derivatives containing quinoxaline moiety

报道了果糖与邻苯二胺反应制得喹喔啉 -2 -甲醛后 ,与芳酰肼作用得到相应的芳酰腙 ,芳酰腙在不同的条件下环化分别得到 1 ,3 ,4 -睧二唑衍生物 ,产物经元素分析、IR、1 HNMR和

Quinoxaline 2 carboxaldehyde(1), obtained from fructose and 1,2 diaminobenzene,condensed with aroylhydrazides to give the corresponding aroylhydrazones(2),which were easily cyclized to 1,3,4 oxadiazole derivatives(3,4) in Ac 2O or Br 2/AcONa.Their structures were determined by IR, 1HNMR,MS and elemental analysis.