脑胶质瘤相关基因1在结肠癌组织中的表达及其临床意义

Expression and clinical significance of glioma-associated oncogene 1 in colon cancer

目的:探讨脑胶质瘤相关基因1(GLi-1)在结肠癌组织中的表达及其临床意义。方法:应用免疫组织化学方法(SP法)检测96例结肠癌组织中GLi-1的表达,并分析其与临床病理因素及术后肝转移的关系。结果:结肠癌组织中GLi-1阳性表达率显著高于正常结肠组织(79.2%vs30.8%,P<0.05),有淋巴结转移组、Dukes分期C+D期组阳性表达显著高于无淋巴结转移及Dukes分期A+B期组(P<0.05);GLi-1阳性表达在年龄、肿瘤大小、性别、分化程度等组间差异无统计学意义(P>0.05)。GLi-1阳性表达组结肠癌术后肝转移时间显著短于阴性表达组(20.46±6.32月vs 48.22±10.03月,P<0.01)。结论:结肠癌组织中GLi-1异常表达参与了结肠癌的发生、发展,对结肠癌术后肝转移有一定的促进作用。

Objective： To investigate the expression and clinical significance of glioma-associated oncogene 1 in colon cancer.Methods： Expression of GLi-1 was detected immunohistochemically in paraffin imbedded specimens of 96 cases with colon cancer.Relationships between GLi-1 expression and clinicopathological parameters,postoperative liver metastasis were analyzed.Results： The ratio of positive expression of GLi-1 in colon cancer was significantly higher than normal colon tissues（79.2%vs 30.8%,P〈0.05）.Significant difference of GLi-1 expression was found between the group of lymph node metastasis and Dukes stage.Patients,postoperative live metastasis-free survival in the group of negative GLi-1 expression was significantly longer than that of positive expression（48.22±10.03 vs 20.46±6.32 months,P〈0.01）.Conclusion： The abnormal activity of GLi-1 may participate in the occurrence and development of colon cancer and GLi-1 promote postoperative liver metastasis of colon cancer.