摘要
主要组织相容性复合体(Major Histocompatibility Complex,MHC)是广泛存在于脊椎动物体内,与免疫相关并编码免疫蛋白受体的基因群。在鱼类中,由于其高度的多态性,使其在遗传、进化以及抗病育种等方面备受青睐。从MHC II类基因的分子结构与功能、克隆及组织分布、遗传特征及基因多态性与抗病力的关系以及MHC II类基因在鱼类研究中的应用进行综述,并对鱼类MHCⅡ类基因未来的研究重点进行展望。
Major histocompatibility complex(MHC) is widespread in vertebrates,and is a gene cluster which encoding immune and immune-related protein receptor.In fish,because of its high polymorphism,it is so favored to the genetic,evolutionary and breeding for disease resistance and so on.The molecular structure and function,cloning and tissue distribution of the MHC II genes,and the relationship between genetic characteristics and disease resistance gene polymorphism were summarized in this paper;and research priorities in fish MHC II in the future were discussed.
出处
《广东农业科学》
CAS
CSCD
北大核心
2012年第3期141-145,共5页
Guangdong Agricultural Sciences
基金
国家罗非鱼产业技术体系建设资金(CARS-49)
关键词
鱼类
MHCII基因
免疫
抗病育种
fish
major histocompatibility complex(MHC) Ⅱ gene
immune
disease resistance.
