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真实世界研究与随机对照试验、单病例随机对照试验在临床治疗性研究中的关系比较 被引量：60

Relationship between the ＇Real World＇ research, randomized controlled trial and number of one randomized controlled trial in clinical therapeutic study
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摘要 真实世界研究、随机对照试验及单病例随机对照试验在设计及具体的实施环节上存在明显不同。随机对照试验属于新治疗措施实施前的研究，真实世界研究属于新治疗措施实施后的研究。两者不是对同一个问题的平行论证，而是承启关系。精心设计的随机对照试验是临床上任何干预措施效果评价的基础，其结果需要真实世界研究的进一步验证及拓展补充，综合考虑二者才是最佳的选择。单病例随机对照试验更易在短时间内获得一些特殊病例的信息，是随机对照试验结果的良好补充，也是一定条件下最经济的真实世界研究。
作者 李敏 时景璞 于慧会
机构地区 中国医科大学附属第一医院临床流行病学教研室辽宁省循证医学中心
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2012年第3期342-345,共4页 Chinese Journal of Epidemiology
关键词 真实世界研究 随机对照试验 单病例随机对照试验 临床治疗性研究 Real world research Randomized controlled trial Number of one randomized controlled trial Clinical therapeutic research
分类号 R259 [医药卫生—中西医结合]
  • 相关文献

参考文献13

  • 1Grapow MT, von Wattenwyl R, Guller U, et al. Randomized controlled trials do not reflect reality: real-world analyses are critical for treatment guidelinesl J Thorac Cardiovasc Surg, 2006,132( 1 ) : 5-7.
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二级参考文献19

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  • 7Cazzoletti L,Marcon A,Janson C,Corsico A,Jarvis D,Pin I,Accordini S,Almar E,Bugiani M,Carolei A,Cerveri I,Duran-Tauleria E,Gislason D,Gulsvik A,Jogi R,Marinoni A,Martinez-Moratalla J,Vermeire P,de-Marco R.Asthma control in Europe:a real-world evaluation based on an international population-based study.J Allergy Clin Immunol.2007;120(6):1360-1367.
  • 8Gale CP,Manda SOM,Batin PD,Weston CF,Birkhead JS,Hall AS.Predictors of in-hospital mortality for patients admitted with ST-elevation myocardial infarction:a real-world study using the Myocardial Infarction National Audit Project (MINAP) database.Heart.2008;94(11):1407-1412.
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共引文献98

同被引文献555

引证文献60

二级引证文献422

中华流行病学杂志
2012年 第3期

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