新生儿缺氧缺血性脑病早期治疗及预后分析

Analysis on early treatment and prognosis of neonatal hypoxic-ischemic encephalopathy

目的:探讨新生儿缺氧缺血性脑病早期治疗的临床效果。方法:收集近期北京市房山区妇幼保健院儿科收治的50例新生儿缺氧缺血性脑病患儿作为观察组,并将之前采用常规治疗的20例患儿作为对照组,观察组在对照组的基础上联合脑活素及复方丹参注射液,分析比较两组临床疗效。结果:观察组显效率、总有效率分别为56.0%、98.0%,均显著优于常规治疗的对照组(P<0.05),观察组治疗1个疗程后与出生后4周NBNA评分均明显优于对照组(P<0.05),两组不良反应率均较低。结论:脑活素及复方丹参注射液联合治疗新生儿缺氧缺血性脑病的临床疗效确切,且安全性良好。

Objective： To explore the clinical efficacy of early treatment of neonatal hypoxic - ischemic encephalopathy （HIE） . Methods： A total of 50 neonates with HIE who were treated in pediatric department of the hospital were collected as observation group, and 20 neonates with HIE who were treated with routine treatment were selected as control group, the neonates in observation group were treated with cerebrolysin combined with compound salvia miltiorrhiza injection based on control group, the clinical efficacies in the two groups were analyzed and compared. Results： The obvious effective rate and total effective rate in observation group were 56.0% and 98. 0%, respec- tively, which were significantly higher than those in control group （P 〈 0. 05 ） . NBNA scores after one course of treatment and at four weeks after birth in observation group were significantly higher than those in control group （P〈0. 05 ）, the incidences of adverse reactions in the two groups were low. Conclusion： Cerebrolysin combined with compound salvia miltiorrhiza injection is effective in treatment of neonatal HIE, and the safety is good.