祥云县已婚育龄夫妇不良妊娠结局相关因素病例对照研究

A case-control study of related factors of adverse pregnancy outcome among the married couples at childbearing age in Xiangyun county

目的:探讨已婚育龄夫妇不良妊娠结局发生的危险因素,为制定干预措施、实现优生优育提供依据。方法:随机选取67例不良妊娠结局已婚育龄夫妇,按照1∶1配对的原则选取67例正常妊娠结局的已婚育龄夫妇作对照,调查可能对两组已婚育龄夫妇不良妊娠结局有影响的相关因素,采用SPSS软件对所有调查因素进行单因素与多因素Logistic回归分析。结果:经Logistic回归模型进行单因素分析,有统计学意义的危险因素有已婚育龄夫妇的年龄(女:OR值=0.585,男:OR值=0.536)、受教育年限(女:OR值=2.982,男:OR值=2.811)、已婚育龄妇女是否曾经怀孕过(包括曾经非意愿流产、早产、不良妊娠结局以及正常分娩等,OR值=2.210)、丈夫的体重指数(OR值=0.370)、丈夫是否吸烟(OR值=11.400)以及丈夫现在是否戒烟(OR值=0.098)。经Logistic回归模型进行多因素分析,有统计学意义的危险因素有丈夫是否吸烟(OR值=8.313)、丈夫是否戒烟(OR值=0.082)。结论:已婚育龄夫妇的年龄、受教育年限、已婚育龄妇女是否曾经怀孕过(包括曾经非意愿流产、早产、不良妊娠结局以及正常分娩等)、丈夫的体重指数等均为不良妊娠结局的危险因素,并且再次证实了吸烟对不良妊娠结局的影响。劝阻丈夫吸烟、减少育龄妇女被动吸烟、控制婚育年龄、避免高龄妊娠、合理饮食以避免过重和肥胖均能够减少不良妊娠结局的发生。

Objective： To explore the risk factors of adverse pregnancy outcome among the married couples at childbearing age, provide a basis for making interventional measures and realizing prepotency. Methods： Sixty-seven married eases at childbearing age with adverse pregnancy outcome were selected randomly, then 67 married cases at childbearing age with normal pregnancy outcome were selected as control group according to 1 ： 1 matched principle. The related effect factors of adverse pregnancy outcome in the two groups were investigated, SPSS software was used to analyze all the factors with univariate and multivariate logistic regression analysis. Results： The results of univariate logistic regression analysis showed that the significant risk factors of adverse pregnancy outcome included ages of the couples （female ： OR = 0. 585 ; male ： OR = 0. 536）, the years for education （ female ： OR = 2. 982 ; male ： OR = 2. 811 ）, pregnancy history of married women （including unwanted abortion, premature birth, adverse pregnancy outcome, and normal delivery） （OR = 2. 210）, body mass indexes of their husbands （ OR = 0. 370）, smoking or not of their husbands （ OR = 11. 400）, and quitting smoking or not of their husbands （ OR = 0. 098） . The results of multivariate logistic regression analysis showed that the significant risk factors of adverse pregnancy outcome included smoking or not of their husbands （ OR = 8.313 ） and quitting smoking or not of their husbands （ OR = 0. 082） . Conclusion： The risk factors of adverse pregnancy outcome among the married couples at childbearing age include ages of the couples, the years for education, pregnancy history of married women （ including unwanted abortion, premature birth, adverse pregnancy outcome, and normal delivery）, and body mass indexes of their husbands, which reconfirm the effect of smoking on adverse pregnancy outcome. Quitting smoking, reducing passive smoking of the women at childbearing age, controlling the marriage age and childbearing age, avoiding elderly pregnancy, reasonable diet to avoid overweight and obesity can reduce the occurrence of adverse pregnancy outcome.