染色体多态性与单精子卵泡浆内注射辅助生殖妊娠结局的关系

Relationship between chromosomal phlymorphism and pregnancy outcome of assisted reproduction by intracytoplasmic sperm injection

目的:探讨染色体多态性与单精子卵泡浆内注射(ICSI-ET)辅助生殖的妊娠结局的关系。方法:对拟行IC-SI助孕患者进行常规外周血淋巴细胞培养,采用G显带技术,通过染色体的核型分析,比较染色体多态性组与染色体核型正常组患者的临床妊娠率、早期流产率和种植率。结果:染色体多态性组与正常组相比,胚胎种植率(29.4%vs 26.8%)、临床妊娠率(46.3%vs 50.8%)和早期流产率(10.5%vs 8.2%)均无统计学差异(P>0.05)。结论:染色体多态性对于ICSI-ET助孕患者的种植率、临床妊娠率、早期流产率无明显影响。

Objective： To explore the relationship between chromosomal phlymorphism and pregnancy outcome of assisted reproduction by intracytoplasmie sperm injection （ISCI） . Methods： The cases planning for assisted reproduction by ISCI underwent conventional lymphocytes culture in peripheral blood, G banding technique and chromosomal karyotype analysis were used to compare the clinical pregnancy rate, early abortion rate, and implantation rate between chromosomal polymorphism group and normal chromosomal karyotype group, Results： There was no significant difference in the embryo implantation rate （29.4% versus 26. 8% ）, clinical pregnancy rate （4dl 3% versus 50. 8% ）, and early abortion rate （101 5% versus 8.2% ） between the two groups （P 〉0. 05） . Conclusion： Chromosomal polymorphism has no impact on the implantation rate, clinical pregnancy rate, and early abortion rate among the cases receiving assisted reproduction by ISCI.