摘要
用动物活体核磁共振Ｔ２分布像和Ｔ１加权像分别观测了超顺磁性氧化铁造影剂和电中性大分子锰配合物造影剂的实验结果。大白鼠肝部的活体测量结果显示，上述两种造影剂能分别显著地改变生物活体组织的Ｔ２和Ｔ１值．该实验结果对于磁共振造影剂的研制和人体的临床试验具有参考价值．
The experimental results of superparamagnetic iron oxide contrast agent and electronic neutral metal complex of manganese contrast medium were observed by magnetic resonance T_2 imaging and T_1-weighted imaging, respectively. The data measured from the images of rat's liver in vivo show that the two types of contrast media are able to change remarkably the T_2 and T_1 of tissue of rat liver, respectively. The experimental results have high value as a reference to research of MRI contrast agents and the clinic application.
基金
中国科学院"九五"基础性重大项目资助
关键词
造影剂
核磁共振成象
超顺磁性氧化铁
Imaging contrast agent, Magnetic resonance imaging, Superparamagnetic iron oxides, Macromolecular complex
