Tau蛋白在胃癌中的表达及其临床意义

Clinical significance of Tau protein expression in gastric cancer

目的探讨Tau蛋白在胃癌中的表达情况及其与临床病理特征之间的关系。方法采用免疫组化法检测44例胃癌标本中Tau蛋白的表达。结果 Tau蛋白的阳性表达率(++～+++)为63.63%(28/44),其中(+++)表达率为11.36%(5/44),(++)表达率为52.27%(23/44);(+)表达率为36.36%(16/44)。Tau蛋白表达与性别、年龄、浸润深度、淋巴结转移、分化程度、TNM分期均无关。结论 Tau蛋白在胃癌中有较高表达,其与胃癌临床病理特征的关系有待进一步研究。

Objective To investigate the expression of Tau protein in gastric cancer and the correlation between its expression and clinicopathological characteritics of gastric cancer.Methods Tau protein expression was examined by immunohistochemistry in 44 gastric adenocarcinoma specimens.Results The rate of Tau protein expression（＋＋＋） was 11.36%（5/44）,（＋＋）was 52.27%（23/44） and（＋）was 36.36%（16/44）.The positive rate of Tau protein overexpression（＋＋-＋＋＋） was 63.63%（28/44）.Tau protein expression was not associated with sex,age,invasion depth,lymph node metastasis,tumor histotype,differentiation and TNM stage.Conclusion Tau protein is overexpressed in gastric cancer.The relationship between Tau protein and clinicopathological characteritics of gastric cancer needs further research.