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白细胞介素-17／Th17细胞与血管炎性疾病 被引量：2

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摘要 CD4＋辅助性T淋巴细胞是一群由多个亚型细胞共同组成的复杂细胞群，包括Th1细胞、Th2细胞、调节性T细胞和Th17细胞。这些细胞来源于共同的原始T淋巴细胞，在体内不同的微环境下发育为生物学功能有显著差异、甚至完全相反的各类效应细胞，并分别具有各自特异的转录因子。Th17细胞是最近发现的CD4＋辅助性T细胞亚群，在自身免疫性疾病和慢性炎症的发病、发展、转归过程中有非常重要的作用。
作者 徐雪 薛愉 邹和建
机构地区 复旦大学附属华山医院风湿科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2012年第3期209-211,共3页 Chinese Journal of Rheumatology
关键词 TH17细胞 白细胞介素-17 血管炎性疾病 辅助性T淋巴细胞 辅助性T细胞亚群 自身免疫性疾病 调节性T细胞 CD4+
分类号 R593 [医药卫生—内科学]
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  • 1王亚萍,沈辉君,刘爱民.儿童过敏性紫癜288例临床分析[J].中华皮肤科杂志,2005,38(7):453-454. 被引量：15
  • 2Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell, 2000, 101: 455-458.
  • 3Park H, Li ZX, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nat Immunol, 2005, 6:1133-1141.
  • 4Chen Z, Tato CM, Muul L, et al. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum, 2007, 56: 2936-2946.
  • 5Singh SP, Zhang HH, Foley JF, et al. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol, 2008, 180: 214-221.
  • 6Kimura A, Naka T, Kishimoto T. IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells. PNAS, 2007, 104: 12099-12104.
  • 7Korn T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammatory T (H)17 cells. Nature, 2007, 448: 484-487.
  • 8Zhou LA, Ivanov II, Spolski R, et al. IL-6 programs T (H)-17 cell differentiation by promoting sequential engagement of the IL- 21 and IL-23 pathways. Nat Immunol, 2007, 8: 967-974.
  • 9Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17- producing CD4^+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol, 2005, 6: 1123-1132.
  • 10Weaver CT, Hatton RD, Mangan PR, et al. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Ann Rev Immunol, 2007, 25: 821-852.

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  • 1Chen SJ,Zhou GB,Zhang XW,et al.Froman old remedy to amagic bullet:molecular mechanisms underlying the therapeuticeffects of arsenic in fighting leukemia[J].Blood,2011,117;6425-6437.
  • 2Zhang XW,Yan XJ,Zhou ZH,et al.Arsenic trioxide controls thefate of the PML-RARalpha oneoprotein by directly binding PML[J].Science,2010,328:240-243.
  • 3Belkaid Y.Regulatory T cells and infection:a dangerous necessity[J].Immunol,2007,7:875-888.
  • 4Bobe P,Bonardelle D,Benihoud K,et al.Arsenic trioxide:apromising novel therapeutic agent for lymphoproliferative andautoimmune syndromes in MRL/lpr mice[J].Blood,2006,108:3967-3975.
  • 5Singer M,Trugnan C,Chelbi-Alix MK.Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclearfactor-kappaB down-regulation and caspase-3 activation[J].Innate Immun,2011,17:365-374.
  • 6Kavian N,Marut W,Servettaz A,et al.Arsenic trioxide preventsmurine sclerodermatous graft-versus-hostdisease[J].J Immunol,2012,188:5142-5149.
  • 7Cho Y,Ahn KH,Back MJ.Age-Related Effects of SodiumArsenite on Splenocyte Proliferation and Th1/Th2 CytokineProduction[J].Arch Pharm Res,2012,35:375-382.
  • 8Yan S,Zhang QY,Zhou B,et al.Arsenic Trioxide Attenuated theRejection of Major Histocompatibility Complex Fully-MismatchedCardiac Allografts in Mice[J].Transplantat Proc,2009,41:1855-1858.
  • 9Facciabene A,Motz GT,Coukos G.T-regulatory cells:keyplayers in tumor immun escape and angiogenesis[J].Cancer Res,2012,72:2162-2167.
  • 10Thomas-Schoemann A,Batteux F,Mongaret C,et al.ArsenicTrioxide Exerts Antitumor Activity through Regulatory T CellDepletion Mediated by Oxidative Stress in a Murine Model of ColonCancer[J].J Immunol,2012,189:5171-5177.

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中华风湿病学杂志
2012年 第3期

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