不同运动强度对高脂血症小鼠血脂的调节作用研究

Regulation of Different Exercise Intensities on Blood Lipids in Hyperlipidemic Mice

目的:研究不同运动强度对高脂血症小鼠血脂反应及代谢的影响,阐明运动对高脂血症小鼠提供非药物治疗的一种方便可行的调节机制。方法:通过小鼠建模对照实验,随机分为正常对照组、洛伐他汀治疗组、高脂模型组及跑步干预组4组对照。对跑步干预组又进行高、中、低3种强度的跑步运动,21天后测定血清、肝的胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C),得到数据并分析。结果:跑步干预21天后,高脂模型组的小鼠的血清、肝脏的TC、TG水平均高于跑步干预的3组和洛伐他汀治疗组;高强度跑步干预组各项指标与洛伐他汀治疗组相近且接近正常对照组。结论:跑步运动在高强度情况下对降脂有明显效果,与洛伐他汀治疗组相比无显著性差异;中、低强度情况下效果不明显,因此,高强度的运动能有效地预防及治疗高脂血症。

Objective.. To study the influence of different exercise intensities on reaction and high blood lipid metabolism in hyperlipidemia in mice and explain the regulation mechanisms of exercise on hyperlipidemia in mice with providing a convenient non-pharmacological treatment, Methods：Modeling of control experiments in mice was randomly divided into normal control group, lovastatin treatment group, model group and four groups were run in the intervention group. Intervention group was on the run for high, medium, and low-intensity treadmill exer- cise, 21 d after the serum, liver cholesterol （TC）, triglyceride （TG）, high-density lipoprotein targets （HDL-C）, and data obtained was analyzed. Results： After running 21d intervention, model group mice serum, liver TC, TG were higher than running the three intervention groups and lovastatin treatment group; High-intensity running in the intervention group and the lovas- tatin treatment group, the indicators are similar and close to the normal control group. Conclu- sion ： Running in the case of high intensity had a marked effect on lipid-lowering with lovastatin treatment group showed no significant difference; In the case of low-intensity, the effect is not obvious, so the high-intensity exercise can be effective prevention and treatment of hyperlipidemia.