胱抑素C水平与冠心病的相关性研究

Correlation between cystatin C level and coronary heart disease

目的了解胱抑素C水平与冠状动脉病变严重程度的关系。方法选择疑诊冠心病且行选择性冠状动脉造影的冠心病患者114例(冠心病组).根据临床病史和冠状动脉造影结果分为2组:急性冠状动脉综合征(acute coronarysyndromes,ACS)组73例,稳定性心绞痛(stable angina pectoris,SAP)组41例;另选择非冠心病(冠状动脉造影阴性)患者38例作为对照组。采用Gensini评分系统对冠状动脉病变程度进行评分。应用免疫比浊法测定血清胱抑素C水平。分析血清胱抑素C水平与冠状动脉病变严重程度及病变支数的相互关系。结果 ACS组和SAP组血清胱抑素C水平明显高于对照组[(2.2±3.5)mg/L vs(1.6±4.1)mg/L vs(0.7±2.9)mg/L,P<0.01].且ACS组血清胱抑素C水平明显高于SAP组(P<0.05)。Gcnsini积分≥30分患者血清胱抑素C水平明显高于Gensini积分<30分患者[(2.6±2.7)mg/L vs(1.8±5.2)mg/L,P<0.01]。3支病变患者血清胱抑紊C水平和Gensini积分较单支病变和双支病变患者明显增高[(2.8±1.8)mg/L vs(1.9±3.4)mg/L vs(2.1±4.1)mg/L;(49±16)分v5(17±9)分vs(28±1 8)分,P<0.05,P<0.01];双支病变患者Gensin积分较单支病变患者明显增高(P<0.01);而单支病变与双支病变患者血清胱抑素C水平差异无统计学意义(P>0.05)。血清胱抑素C水平与冠状动脉病变严重程度Gensini积分呈正相关(r=0.673,P<0.01)。结论胱抑素C水平与冠状动脉病变严重程度及病变支数显著相关,胱抑素C水平可以作为评价冠状动脉病变严重程度的一个指标。

Objective To study the correlation between cystatin C level and severity of coronary heart disease（CHD）. Methods One hudred and fourteen patients with CHD were divided into acute coronary syndrome（ACS） group（n= 73） and stable angina pectoris（SAP） group（n= 41）. Thirty-eight non-CHD patients with negative coronary angiogragraphy（CAG） served as a control group. Severity of CHD was scored using the Gensini scoring system. Correlation of serum cystatin C level and severity of CHD with lesions of coronary arteries was analyzed. Results The serum cystatin C level was significantly higher in ACS group and SAP group than in control group （2.2±3.5 mg/L vs 1.6±4. 1 mg/I. vs 0. 7±2. 9 mg/L,P〈0.01）,in ACS group than in SAP group（P〈0. 05）, in patients with their Gensini score ≥30 than in those with their Gensini score〈30（2.6±2.7 mg/L vs 1.8±5.2 mg/L,P〈0.01） ,and in patients with triple vessel disease than in those with single Vessel disease（P〈0. 01）,but no significant difference was found be tween patients with triple vessel disease or single vessel disease（P〉0.05）. The cystatin C level was positively correlated the Gensini score of CHD severity （r= 0. 673, P〈0.01）. Conclusion Cystatin C level is significantly correlated with the severity of CHD and the number of compro raised coronary arteries,and can thus be used as a marker in assessing the severity of CHD.