1652例泌尿生殖道感染患者支原体检测与药敏分析

Analysis of Drug Sensitivity and Detection of Mycoplasma of 1652 Patients with Genitourinary Tract Infection

目的:分析苏州市第五人民医院2009年泌尿生殖道感染患者支原体的检测及药敏情况,为临床治疗及合理用药提供依据。方法:采用法国梅里埃生物公司提供的IST试剂盒做支原体培养鉴定和药敏试验,并对结果进行统计分析。结果:1652例患者中分离出支原体511株,标本阳性率为30.93%,其中解脲支原体(Uu)阳性率为82%,人型支原体(Mh)阳性率为1.37%,Uu+Mh混合型阳性率为16.63%;药敏结果显示,支原体对普那霉素、多西环素、交沙霉素、四环素敏感率的平均值分别为100.00%,97.24%,95.75%,90.83%;对环丙沙星、氧氟沙星敏感率的平均值分别为10.54%,9.67%。结论:普那霉素、多西环素、交沙霉素、四环素可作为泌尿生殖道支原体感染的临床经验性选用的抗菌药物,同时应加强对支原体的耐药性的监测,指导临床合理使用抗菌药物。

Objective： To analyze the anti-microbial susceptibility and detection of Mycoplasma of patients with genitourinary tract infection in 2009 in Suzhou No.5 people＇s hospital and to provide a basis for the rational use of drugs for clinical treatment .Methods： Biomerieux IST kit was used for identification and susceptibility testing of the Mycoplasma strains.Results： Specimens positive rate was 30.93% in 1 652 patients with Mycoplasma. Of the Mycoplasma detected, Ureaplasma urealyticum（Uu） was alone 82%, Mycoplasma huminis（Mh） was 1.37%, and Uu＋Mh was indentified in 16.63%.The results of anti-microbial susceptibility testing showed that the Mycoplasma isolates were the most susceptible to pristinamycin, doxycycline, josamycin and tetracycline： 100%, 97.24%, 95.75% and 90.83% respectively. Ciprofloxacin and ofloxacin were the most susceptible and the sensitive rate of the Mycoplasma to ciprofloxacin and ofloxacin was 10.54% and 9.67% separately. Conclusion： Pristinamycin, doxycycline, josamycin and tetracycline can be used in the treatment of genitourinary tract infections caused by Mycoplasma. The Mycoplasma isolates must be screened for the potential trend of resistance for guiding rational anti-microbial therapy.