突触结构中线粒体的功能及对高胆红素血症的影响
摘要
正常生理调节下,线粒体对需氧细胞(包括神经细胞)的功能至关重要,提供能量三磷酸腺苷(ATP)、参与活性氧簇代谢和Ca^2+信号传递及细胞凋亡等,是维持正常代谢所必需的。但在异常情况下,线粒体也可以是神经细胞损伤的原因:兴奋性细胞毒性,不完全代谢,氧化损失直至细胞死亡,造成神经系统病变。神经末梢内线粒体通过能量产生的变化、Ca^2+摄取和释放等对神经递质电活动产生反应。
出处
《实用医技杂志》
2012年第3期278-279,共2页
Journal of Practical Medical Techniques
参考文献7
-
1Macaskill AF,Rinholm JE,Twelvetrees AE,et al.Mirol is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.Neuron,2009,61(4):541-555.
-
2Zhao XL,Wang WA,Tan JX,et al.Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in droso-phila.J Neurosci,2010,30(4):1512-1522.
-
3Dupuis L,de Gonzalez-Aguilar JL,Echaniz-Laguna A,et al.Muscle mitochondrial uncoupling dismantles neuromuscular jun-cion and triggers distal degeneration of motor neurons.PLoS One,2009,4(4):5390.
-
4Jiang D,Zhao L,Clapham DE.Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.Science,2009,326(5949):144-147.
-
5Guo X,Macleod GT,Wellington A,et al.The GTPase dMiro is required for axonal transport of mitochondria to drosophila synapses.Neuron,2005,47(3):379-393.
-
6Vaz AR,Delgado-Esteban M,Brito MA,et al.Bilirubin selec-tively inhibits cytochrome c oxidase activity and induces apopto-sis in immature cortical neurons:assessment of the protective effects of glycoursodeoxycholic acid.J Neurochem,2010,112(1):56-65.
-
7Malik SG,Irwanto KA,Ostrow JD,et al.Effect of bilirubin on cytochrome c oxidase activity of mitochondria from mouse brain and liver.BMC Res Notes,2010,3:162.
-
1付建军.用马钱子治疗神经系统病变的效果研究[J].当代医药论丛,2015,13(14):33-35.
-
2晋志高,蒋瑾,逯波,田德全,王洪才,陈丁生,朱丽霞.针刺对糖尿病大鼠神经系统病变的治疗作用[J].上海针灸杂志,2000,19(S1):57-58. 被引量:3
-
3董慧咏,董振咏.桂枝加附子汤加减合济生肾气丸治疗糖尿病性疼痛临床观察[J].河北中医,2008,30(5):499-500. 被引量:2
-
4刘秋娈.运用补阳还五汤治疗神经系统病变的体会[J].山西中医学院学报,2002,3(4):32-33. 被引量:1
-
5左萍萍,张世仪,陶沂.764-3对脑突触小体Ca^(2+)摄取的抑制作用[J].基础医学与临床,1995,15(4):72-72. 被引量:1
-
6仲夏.三七提前采挖行 情岌岌可危[J].全国药材信息,2013(21):4-4.
-
7赵聃,东野星竹,张彤.吊针加太阳穴位注射治疗面肌痉挛临床观察[J].山东中医杂志,2014(3):202-202.
-
8刘蔚东,严慧平(整理).便秘不只是缺纤维素[J].老年健康,2010(12):14-14.
-
9况时祥.运用马钱子治疗神经系统疾病探讨[J].河南中医,2004,24(1):72-73. 被引量:11
-
10王红梅.穴位注射治疗面肌痉挛56例临床观察[J].中医药学报,2003,31(3):56-56.