用数学方法设计固定化产腈水解酶细胞填充床反应器的关键操作参数

Design of Key Operational Parameters of Immobilized Nitrilase-Producing Cells Packed-Bed Reactor by Methimatical Method

在用固定化产腈水解酶细胞填充床反应器催化制备尼克酸的实验中,通过构建代数形式的经验方程,成功地完成了反应器操作参数的设计。通过分析已知的填充床反应器的轴向扩散模型(一维)的数值解,得到一个经验方程:L=7.898u cS0+114.6u+0.028,该方程描述了3个关键操作参数(柱长L,流速u和底物浓度cS0)之间的关系。在底物转化率和反应器孔隙率分别为95%和0.11的前提下,以所得的代数方程为约束条件进行了最优化计算,求解出最优操作参数,使尼克酸的产量达到最高。

By constructing an empirical equation with algebraic form,the key operational parameters of immobilized nitrilase-producing cells packed-bed reactor were determined successfully for nicotinic acid production.A simplified equation,L=7.898u cS0＋114.6u＋0.028,which describes the relationship of the three key operational parameters（column length L,flow rate u and substrate concentration cS0）,was obtained by analyzing the numerical solutions of the established axial dispersion model（one-dimension） of packed-bed reactor.Under the condition of 3-cyanopyridine conversion rate of 95% and the void fraction of 0.11,the optimal operational parameters of packed-bed reactor were obtained by computation based on the algebraic equation for the purpose of maximization of the nicotinic acid production.