利奈唑胺治疗老年肺部感染对血小板的影响

Effects of Linezolid on Platelet during Treatment of Elderly Patients with Lung Infection

目的评价利奈唑胺对住院老年肺部感染患者血小板的影响。方法回顾性分析13例住院老年患者肺部感染后应用利奈唑胺治疗的临床资料。结果 13例应用利奈唑胺抗感染治疗的患者,7例发生血小板减少,发生率为53.85%,在用药第3～12天,平均(6.4±2.5)d开始出现血小板下降,第6～12天,平均(9.4±2.6)d降至最低,有2例出血,7例患者均停用利奈唑胺,其中2例输注血小板,1例输注血浆,停药后3～6 d,平均(4.1±1.1)d血小板开始回升,停药后6～12 d,平均(10.0±3.2)d恢复至正常水平。结论利奈唑胺在治疗住院老年肺部感染患者时,血小板减少发生率较高;临床选用利奈唑胺要慎重,治疗期间和治疗后严密监测血小板。

Objective To evaluate the effects of linezolid on platelet in the process of treating elderly patients with gram-negative bacteria affected lung infection.Methods Clinical data of 13 elderly patients with lung infection who were treated with linezolid were analyzed retrospectively.Results There were 7 elderly patients developed thrombocytopenia,and the incidence of which was 53.85%.The reduction of platelet developed on the third to twelfth day of linezolid usage,and the lowest platelets count occurred on the sixth to twelfth day.There were 2 cases of thrombocytopenia with bleeding complications.All the 7 cases terminated using linezolid,in which there were 2 cases infused with platelet and 1 with plasma.The platelets counts rose again on the third to sixth day after linezolid withdrawn,and the platelet resumed to the normal level on the sixth to fourteenth day.Conclusion When elderly in-patients with lung infection receive linezolid against gram-negative bacteria,the incidence of thrombocytopenia turns high.In clinical settings,we should choose linezolid carefully and monitor platelet counts closely in the course of using linezolid and post-treatment.