小牛脾提取物联合FOLFOX方案治疗晚期结直肠癌的临床观察

Sipulin in combination with FOLFOX regimen for treatment of advanced colorectal cancer

目的评价小牛脾提取物联合FOLFOX方案治疗晚期结直肠癌的疗效与安全性。方法小牛脾取物10 ml+5%葡萄糖注射液250 ml静滴,奥沙利铂130 mg/m2第1天,亚叶酸钙200mg/m2第1～天5,5-氟尿嘧啶300/m2第1～5天,21 d为1个周期。结果本组有效率(CR+PR)53.1%,不良反应较对照组轻。结论小牛脾提取物联合FOLFOX方案治疗中晚期结直肠癌疗效较高,不良反应轻。

Objective To evaluate the efficacy and safety of sipulin in combination with FOL- FOX2regimen in treatment of patients with advanced colorectal. Methods Sipulin 10 ml ＋ 5% GS 250 ml ivgtt dl-10,OXA 130 mg/m/dl ,LV 200 mg/m^2dl-5,5-Fu 300 mg/m^2d1-5,21 day cycle. Results The overall response rate （CR ＋ PR）was 53.1%, adverse reaction is lower than the control group. Conclusinon Sipulin in combination with FOLFOX regimen has highly effective regimen for advanced colorectal cancer with mild toxicity and can be used safely.