GST-π和Topo-Ⅱ在初诊弥漫大B细胞淋巴瘤中的表达及其与国际预后指数评分的关系

The clinical significance of GST-π,Topo-II in diffuse large B-cell lymphoma and its relationship with IPI score

目的本研究通过免疫组化方法检测初诊弥漫大B细胞淋巴瘤(DLBCL)患者淋巴组织GST-π、Topo-Ⅱ的表达,探讨初诊DLBCL患者上述指标表达的临床意义以及与IPI积分的相关性。方法收集福建省立医院病理科存档的2006年10月1日至2010年10月1日期间,首次确诊DL-BCL且接受化疗(CHOP或R-CHOP方案)≥2疗程患者标本34例(其中27例完成6个疗程化疗),检测GST-π、Topo-Ⅱ的表达。入选病例根据国际预后指数(IPI)进行评分,将评分结果分别与所检测指标的表达结果进行相关分析;将患者2、6个疗程化疗后疗效分别与IPI积分、上述两项结果进行相关分析。结果 GST-π、Topo-Ⅱ高表达与IPI评分密切相关,其阳性表达与IPI评分呈正相关。2个疗程化疗疗效及6个疗程化疗疗效都与两项指标呈正相关。结论在初治DLBCL患者中,GST-π、To-po-Ⅱ高表达与不良预后相关。

Objective To investigate the expression of GST-π,Topo-II in lymphoid tissues of the first-diagnosis DLBCL patients by immunohistochemistry,and to explore the clinical significance of the expressions and its relationship with IPI score.Methods 34 samples of first-diagnosis DLBCL patients with further chemotherapies involved（CHOP or R-CHOP regimen） were enrolled,which were collected from the department of pathology from 1st Oct,2006 to 1st Oct,2010 in Fujian Provincial Hospital,and the expression of GST-π and Topo-II was examined by immunohistochemistry methods.All the collected patients received no less than 2 periods of treatment and 27 of them received 6 periods totally.The samples were scored by international prognosis index（IPI）,and the relationship between the scores and the expression of GST-π,Topo-II was analyzed.The clinical effect was investigated after 2 to 6 chemotherapies retrospectively.Results The high expression of GST-π,Topo-II was closely related to IPI scores and the positive expression was correlated to IPI scores.The effect of chemotherapy（2 to 6 periods） was also positively correlated to the expression of GST-π,Topo-II and IPI scores.Conclusions The high expression of GST-π and Topo-II indicates the worse prognosis in first-diagnosis DLBCL patients.