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贝伐单抗辐射增敏机制研究进展 被引量：1

贝伐单抗辐射增敏机制研究进展
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摘要 贝伐单抗作为抗血管生成治疗的重要手段,在众多肿瘤治疗中显示了令人欣喜的疗效。但其联合放疗的研究较少,贝伐单抗辐射增敏的机制尚不清楚,我们复习相关文献,就贝伐单抗辐射增敏机制做一综述,以期为临床研究提供思路。
作者 庄洪卿 赵路军 王军 王平 袁智勇
机构地区 天津医科大学附属肿瘤医院放疗科天津市肺癌诊疗中心天津市肿瘤防治重点实验室
出处 《中国肿瘤临床与康复》 2011年第5期477-479,共3页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 贝伐单抗 放疗 辐射增敏 Bevacizumab Radiotherapy Radiosensitivity
分类号 R96 [医药卫生—药理学]
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参考文献21

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同被引文献13

  • 1赵维,付彤,刘国津,张凌.微血管密度和血管内皮因子在肺癌组织中的表达及临床意义[J].吉林大学学报（医学版）,2005,31(4):595-597. 被引量：6
  • 2Hong TS,Wo JY,Kwak EL.Targeted therapies with chemoradiation in esophageal cancer:development and future directions.Semin Radiat Oncol,2013,23:31-37.
  • 3Crane CH,Eng C,Feig BW,et al.Phase Ⅱ trial of neoadjuvant bevacizumab,capecitabine,and radiotherapy for locally advanced rectal cancer.Int J Radiat Oncol Biol Phys,2010,76:824-830.
  • 4Crane CH,Winter K,Regine WF,et al.Phase Ⅱ study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer:Radiation Therapy Oncology Group RTOG 0411.J Clin Oncol,2009,27:4096-4102.
  • 5Niyazi M,Ganswindt U,Schwarz SB,et al.Irradiation and bevacizumab in high-grade glioma retreatment settings.Int J Radiat Oncol Biol Phys,2012,82:67-76.
  • 6Sofia Vala I,Martins LR,Imaizumi N,et al.Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis.PLoS One,2010,5:el 1222.
  • 7Truman JP,Garcia-Barros M,Kaag M,et al.Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.PLoS One,2010,5:el 2310.
  • 8Hoang T,Huang S,Armstrong E,et al.Enhancement of radiation response with bevacizumab.J Exp Clin Cancer Res,2012,31:37.
  • 9Schueneman AJ,Himmelfarb E,Geng L,et al.SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.Cancer Res,2003,63:4009-4016.
  • 10Chira C,Jacob J,Derhem N,et al.Preliminary experience of wholebrain radiation therapy (WBRT) in breast cancer patients with brain metastases previously treated with bevacizumab-based chemotherapy.J Neurooncol,2011,105:401-408.

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中国肿瘤临床与康复
2011年 第5期

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