维生素C与幽门螺杆菌根除的临床研究

Clinic study about impact of vitamin C on eradication rate of helicobacter pylori

目的研究维生素C联合经典的三联疗法对幽门螺杆菌(helicobacter pylori,Hp)的根除率的影响。方法将门诊Hp检测阳性并经胃镜检查证实慢性胃炎的患者120例,随机分为两组。对照组(60例)采用三联疗法7天,治疗组(60例)采用上述三联疗法+维生素C 7天。治疗结束后1月复查14C-尿素呼气试验,计算Hp根除率。并对方案进行成本-效果分析。结果经ITT分析,Hp根除率治疗组与对照组分别为85%和68.33%,治疗组根除率高于对照组(P<0.05);经PP分析,Hp根除率治疗组与对照组分别为87.93%和71.93%,治疗组根除率高于对照组(P<0.05)。成本-效果分析治疗组成本效果比值低于对照组。结论维生素C联合经典的三联疗法能增加Hp的根除率。

Objective： To research the impact of vitamin C on the helicobacter pylori（Hp） eradication rate of the classic triple therapy and then to seek the better treatment that can improve the eradication rate.Methods： 120 chronic gastritis outpatients diagnosed by endoscopy who were helicobacter pylori-infected were enrolled and divided into two groups randomly： the control group who received standard triple therapy,Omeprazole 20mg,Clarithromycin 500mg,and Amoxicillin 1g,twice daily for 7 days and the cure group who received vitamin C 200mg three times daily in addition to standard quadruple therapy for 7 days.After finishing of Hp therapy four weeks later,Hp eradication rate were compared by 14C-urea breath test and cost-effectiveness analysis.Results： By the way of intention-to-treat analysis,eradication rate of therapy group was greater than that of the control one,85% vs 68.33%,P0.05;By the way of per-protocol analysis,87.93% vs 71.93%,P0.05.The cost-effectiveness analysis showed that cost/effectiveness value of the therapy group were lower than the of the control group.Conclusion： Addition of vitamin C to standard triple therapy can achieve a higher eradication rate.