胆固醇7α-羟化酶调节的研究进展

Research progress of the regulation to cholesterol 7α-hydroxylase related to lipid metabolism

胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)是在肝脏合成并促使胆固醇转化成胆酸的限速酶,对维持体内胆固醇代谢平衡起到关键作用。CYP7A1基因表达受脂代谢相关的多个核因子的精细调控,诸如HNF4a,LXR,FXR,SHP和FGF15/19及相关激素等其他因子,以维持胆固醇代谢平衡;多种中药及饮食成分对CYP7A1的基因表达也有明显调节作用,进而影响血脂代谢。本文就近10年来有关CYP7A1调节的研究进展综述如下。

Cholesterol 7α-hydroxylase（CYP7A1）,synthesized in liver,is the rate-limiting enzyme that induces cholesterol converse to bile acid,and it plays a vital role in keeping homeostasis of cholesterol metabolism.The expression of CYP7A1 is well controlled by nuclear factors that related to lipid metabolism such as HNF4a,LXR,FXR,SHP,FGF15/19 and other hormones.Some traditional Chinese medicine and food ingredients also show regulation to CYP7A1.This paper will make a summary for references about the related research progress on CYP7A1 in recent decades.