术前介入动脉化疗对Ⅰb_2～Ⅱb期宫颈鳞癌根治术影响的研究

Study on the Effect of Preoperative Intraarterial Interventional Chemotherapy on Radical Pperation of Ⅰb_2～Ⅱb Stage Cervical Scale Carcinoma

目的:探讨术前介入动脉化疗对Ⅰb2～Ⅱb期宫颈癌的近期疗效。方法:将71例Ⅰb2～Ⅱb期宫颈鳞癌患者随机分为两组:介入组38例术前予以介入子宫动脉化疗(顺铂40～60 mg+5-氟脲嘧啶750～1000 mg+丝裂霉素8～10 mg),介入治疗后3周进行宫颈癌根治术;对照组33例直接行宫颈癌根治术。结果:介入组介入治疗后肿瘤退缩明显,术后病理阴道残端及宫旁切缘均未见癌侵及,介入组与对照组相比,侵及宫颈肌层大于1/2、脉管癌栓、淋巴结转移均较直接手术组低,差异有统计学意义。结论:Ⅰb2～Ⅱb宫颈癌根治术前介入动脉化疗有一定近期疗效,为手术创造了条件。

Objective：To explore the short term effectiveness of intraarterial interventional chemotherapy for Ib2~Ⅱb uterine cervical carcinoma before operation.Methods：All 71 patients with uterine cervical scale carcinoma were randomized divided into intervention group（38 cases） and control group（33 cases）.Thirty eight patients in intervention group were treated with in terventional chemotherapy before operation including 40~60 mg cisplatin,750~1 000 mg 5-FU and 8~10 mg mitomycin.The radical operation of cervical carcinoma was taken in three weeks after intraarterial chemotherapy.Thirty three patients in control group were directly treated with radical operation of cervical carcinoma.Results：The diameters of tumor after interventional chemotherapy were obviously lessened,cancer can not be found in vaginal residual and incision edge of uterine palace after operation.Compared intervention group with the control,There was significant difference about penetrating half of cervical muscle layer、vascular tumor emboli and lymph node metastasis.Conclusions：The intraarterial chemotherapy can improve the condition of operation,its short term outcome is very good.