碘催化苯甲醚的苯甲酰化反应

Benzoylation Reaction of Anisole Using Iodine as Catalyst

在碘催化作用下,以苯甲醚和苯甲酰氯为原料,通过Friedel-Crafts酰基化反应合成对甲氧基二苯甲酮。考察了原料物质的量比、催化剂用量以及反应温度和时间等因素对产品收率的影响。确定的适宜工艺条件为:苯甲醚0.1mol,苯甲醚与苯甲酰氯的物质的量比为1.0:1.5,催化剂质量为1.5g,反应温度140℃,反应时间为4.0h,产物收率达59.0%。

4-Methoxybenzophenone was synthesized from Fridel-crafts acylation of anisole and benzoyl chloride using iodine as catalyst.The effects of reactant ratio,amount of catalyst used,reaction temperature and time were investigated.The suitable reaction conditions were optimized as： anisole was 0.1 mol,anisole / benzoyl chloride mole ratio was 1.0∶1.5,catalyst usage was 1.5 g,reaction temperature was 140 ℃,reaction time was 4 h.The highest yield of 61.68 % is obtained.