Th1/Th2型细胞因子平衡与正常妊娠的关系

The relationship between normal pregnancy and helper T cell 1/helper T cell 2 cytokines balance

目的:探讨Th1/Th2型细胞因子平衡与正常妊娠之间的关系。方法:采用酶联免疫吸附方法检测40例非妊娠妇女和42例正常妊娠妇女的血清中Th1型细胞因子(IL-2 I、FN-γ、TNF-α和IL-1β)及Th2型细胞因子(IL-4、IL-6 I、L-10和IL-13)的表达水平。结果:非妊娠组相比,妊娠组血清中IL-2和TNF-α的表达水平明显降低(P值均<0.05)I,L-4和IL-10的表达水平明显升高(P值均<0.05);而两组血清中IFN-γI、L-1βI、L-6和IL-13表达水平的差异无统计学意义(P值均>0.05)。结论:正常妊娠是以分泌Th2型细胞因子为主的,提示Th1/Th2型细胞因子的平衡可能在正常妊娠中发挥重要作用。

Aim： To investigate the relationship between normal pregnancy and Thl/Th2 cytokines bal-ance. Methods： The concentrations of Thl cytokines （IL-2 ,IFN-γ,TNF-α and IL-1β） and Th2 cytokines（IL-4,IL-6,IL-10 and IL-13 ） in the serum of 40 normal non-pregnant women and 42 normal pregnantwomen were measured by enzyme-linked immunosorbant assay （ELISA）. Results： The concentrations ofIL-2 and TNF-α in the serum of normal pregnancy group were significantly lower than those in normal con-trol group （P 〈0. 05） , while the concentrations of IL-4 and IL-IO in the serum of normal pregnancy groupwere significantly higher than those in control group （P 〈 0. 05 ）. The difference of the concentrations ofIFN-γ,IL-1β ,IL-6 and IL-13 in the serum of the two groups was not significant （P 〉 O. 05 ）. Conclusion：The results suggest that women in normal pregnancy had mainly the Th2 cytokines. The results provideclue that Thl/Th2 cytokines balance may play a important role in normal pregnancy.